Rational antibiotic use is thus required in dental and oral clinical practice to ensure maximum efficacy while at the same time minimizing the side effects and the appearance of resistances. Antibiotics are typically prescribed in dental practice for some of the following purposes: treatment for acute odontogenic infections, treatment for non-odontogenic infections, and prophylaxis against focal infection in patients at risk (endocarditis and joint prostheses); and as prophylaxis against local infection and systemic spread in oral surgery.
Doctors have proposed clindamycin as the drug of choice given its good absorption, low incidence of bacterial resistance, and high antibiotic concentrations reached in bone. It is recommended that empirical treatment with beta-lactams associated with fluoroquinolones should be limited since both groups of antibiotics activate common resistance mechanisms – thus favoring the appearance of resistances in important pathogens such as Pseudomonas aeruginosa.
The treatment of specific infections caused by mycobacteria requires the use of antibiotics for long perperiodsrom six months to 2 years) and includes the administration of dapsone (a sulfamide analog), clofazimine (a dye with bactericidal action), rifampicin for leprosy, and associations of ethambutol, isoniazid, rifampicin, pyrazinamide, and streptomycin for tuberculosis.
Precautions with antibiotic use
Pregnant patients have not been advised to use antibiotics since they can affect the fetus. The legal and ethical impossibility of conducting clinical trials in humans to evaluate the risks of antibiotic treatment during pregnancy has given rise to uncertainties about the use of such drugs in these patients.
Kidney failure is also another exception. Many antibiotics are actively eliminated through the kidneys. The presence of impaired renal function requires a reduction of the drug dose to avoid excessively elevated plasma drug concentrations that could lead to toxicity. Liver failure can also be an issue since some antibiotics are metabolized in the liver, followed by elimination in bile.
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Dental Blog - Silverdale, WA • Life Long Dental Dr. Gillespie has created this informative blog to help educate the community. Did you like a topic? Please contact us today! Life Long Dental is your dentist in Silverdale, WA. Life Long Dental, 3100 NW Bucklin Hill Rd, Suite 209, Silverdale, WA 98383-8358 / (360) 633-2377 / lifelongdental.com / 1/29/2023 / Page Phrases: Dentist Silverdale WA /